4-[[(2S)-1-[3-oxo-3-[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]propoxy]propan-2-yl]amino]-5-(trifluoromethyl)-1H-pyridazin-6-one
(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one
CAS: 2381037-82-5
Molecular Formula: C20H23F6N7O3
4-[[(2S)-1-[3-oxo-3-[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]propoxy]propan-2-yl]amino]-5-(trifluoromethyl)-1H-pyridazin-6-one - Names and Identifiers
4-[[(2S)-1-[3-oxo-3-[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]propoxy]propan-2-yl]amino]-5-(trifluoromethyl)-1H-pyridazin-6-one - Physico-chemical Properties
| Molecular Formula | C20H23F6N7O3 |
| Molar Mass | 523.43 |
| Density | 1.53±0.1 g/cm3(Predicted) |
| pKa | 9.56±0.60(Predicted) |
4-[[(2S)-1-[3-oxo-3-[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]propoxy]propan-2-yl]amino]-5-(trifluoromethyl)-1H-pyridazin-6-one - Reference Information
| biological activity | RBN-2397 is an effective, selective, orally active NAD competitive inhibitor PARP7 with IC50 value <3 nM and Kd value <0.001 μM. RBN-2397 has the potential to study tumor therapy. |
| target | TargetValue PARP7 (Cell-Free Assay) <0.001 μM(Kd) PARP7 (Cell-Free Assay) <3 nM |
| Target | Value |
| PARP7 (Cell-free assay) | <0.001 μM(Kd) <3 nM |
Last Update：2024-04-09 20:52:54
![4-[[(2S)-1-[3-oxo-3-[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]propoxy]propan-2-yl]amino]-5-(trifluoromethyl)-1H-pyridazin-6-one](http://res.chembk.com/assets/images/structure/2381037-82-5.gif)